It is an excipient approved for use in pharmaceutical products and is also GRAS listed and accepted for use as a food additive in Europe and the United States and is included in the FDA Inactive Ingredients Database (oral: powders, suspensions, syrups, and tablets; topical & vaginal products). 4 0 obj
This is unlikely to be a problem when Microcrystalline cellulose is consumed as part of a medical product where it is used as an excipient in the formulation. <
gV2@o2s&WS@Et%Up:`U '_ h?8qyP=&> GFprm9A!uu1 }&*kQ c^&eX}^K}h9YCb2L(yL):,+g8_u. The table below shows the most common physicochemical parameters of this raw material. Frijlink, Compaction mechanism and tablet strength of unlubricated and lubricated (silicified) Microcrystalline Cellulose, European journal of Pharmaceutics and Biopharmaceutics, 59 (2005) 133-138. The formed cellulose molecules pack themselves closely to each other, stabilised through hydrogen bonds, creating crystalline regions interspersed with amorphous regions. : 160182. Although the breakup of cellulose to form colloidal microcrystalline cellulose has no impact on calorific content of the material, colloidal microcrystalline cellulose contain soluble components (hydrocolloids) that are introduced during processing, which add calories to the product. Learn about FMC's differentiated biologically-based crop solutions. In many applications, one METHOCEL product can perform the job of two, three or even more ingredients saving money and time. Studies from the World Health Organisation and the European Food Safety Agency have concluded that Microcrystalline cellulose has no safety concerns for the public when used in animal nutrition. iq/iVO"5VI}dn.#q^(fJ),BN
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This unique functionality can be used in a diversity of applications such as controlled release dosage forms, enteric coatings, microencapsulation and stabilization in solutions and suspensions. : 9004-34-6 Date Approved: 01/31/2008 . : 9 This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication . The 'Substance identity' section is calculated from substance identification information from all ECHA databases. Looking for FMC'searnings news? It is highly versatile and is therefore also widely used in topicals and semi-solid & liquid dosage forms, including ointments, creams, gels, pastes, solutions, suspensions, and emulsions. CAS #: 9004-34-6 ChemicalBook. Learn about our new global sustainability platform, Learn about FMC's industry leading goal of net-zero emissions by 2035, Learn about FMC's differentiated biologically-based crop solutions.
PDF MATERIAL SAFETY DATA SHEET - Pfizer <>
Truly distinctive drug delivery solutions. The short-term limit for total inhalable dust is 20 mg/m3. iQuLyI4D@yq#u0dZt=0?QUz{K6by_C"vW~Nj$bo? . Kristensen, T. Schfer, P. Kleinebudde, Direct pelletization in a rotary processor controlled by torque measurements. MATERIAL SAFETY DATA SHEET Lattice NT Microcrystalline Cellulose MSDS Ref. Delivering efficient and robust formulations. 4 0 obj
Avicel RC-591 & CL-611 - Description. Microcrystalline cellulose in certain fiber supplements may cause mild side effects ().These may include gas, bloating and increased stool production.. Superior Performance: Provides excellent water uptake and rapid swelling .
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Microcrystalline cellulose was negative in the Ames mutagenicity assay [FMC Study Number I91-1189], and caused no Avicel Microcrystalline Cellulose is a safe and non-hazardous material that is widely used in pharmaceutical formulations and food products (as a bulking agent and to add crispness). POLYOX resins are nonionic polyethylene oxide solubility polymers. .
PDF Safety Data Sheet - Accentuate Microcrystalline cellulose: The inexhaustible treasure for Microcrystalline Cellulose - an overview | ScienceDirect Topics XiDqLN MD'F2`jI7ZWu,JK%5e9~:R>LAm\WyY0lk=ZNP;pZ23)P0GG~%e[ d8GIXRo&. The Microcrystalline Cellulose monograph will be incorporated into and become official with the Second Supplement to . %&'()*456789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz
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This paper is based on a study of the interactions that take place during the process of hydrogel formation, break down, and recovery. The current product range and recommended usage are summarised below: Microcrystalline Cellulose is currently listed in the United States Pharmacopoeia and National Formulary, the European Pharmacopeia, the Japanese Pharmacopoeia, the British Pharmacopoeia, in addition to the Indian and Chinese Pharmacopeia, to name but a few. If breathing is difficult or if . Product and Company Identification Product Name Microcrystalline Cellulose CAS Number 9004-34-6 Parchem - fine & specialty chemicals 415 Huguenot Street New Rochelle, NY 10801 (914) 654-6800 (914) 654-6899 parchem.com info@parchem.com EMERGENCY RESPONSE NUMBER Avicel Microcrystalline cellulose is composed of insoluble fibre and does not contribute any other material of nutritional importance. /Group << /S /Transparency /CS /DeviceRGB /I false /K false >>
EINECS #: 232-674-9 1.7. Instead, they obtained a stable colloidal suspension. No. LATTICE Microcrystalline Cellulose has many important uses within the food, pharma, specialty applications and industrial such . Explore our commitment to environmental, social, and corporate governance and discover how we are making an impact. 1 0 obj
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Avicel CL-611 Microcrystalline Cellulose and Sodium (Microcrystalline Cellulose Market Pr. CAS #: 9004-34-6 1.6. The representative usage of Avicel PH-101 and Avicel PH-102 Microcrystalline cellulose in wet granulation and direct compression is shown in the following two examples. : 51395-75-6 Date Approved: 01/31/2008 Revision No. The process is relatively basic; and starts with treating cellulose, obtained as a high-grade pulp obtained from fibrous plant material, with mineral acids, followed by purification and spray-drying. An internally cross-linked sodium carboxymethyl cellulose (NaCMC), it aids in the disintegration and drug dissolution of pharmaceutical tablets, capsules, and granules. . To help, weve put together a simple guide for selecting Avicel Microcrystalline cellulose grades, with simple explanations of some of the most common grades, plus recommendations that will serve the majority of buyers. LOT #: Available upon request. ). Gloves, eye protection and a dust mask should be used. The product would later go on to be commercialized under the brand name Avicel by FMC Corporation. It is hygroscopic and insoluble in water.
Global Microcrystalline Cellulose Market (MCC) Size Will Reach US$ 1360 Cellulose microcrystalline Revision Date 25-Dec-2021 SARA 313 Not applicable SARA 311/312 Hazard CategoriesSee section 2 for more information CWA (Clean Water Act) Not applicable Clean Air Act Not applicable OSHA - Occupational Safety and Health Administration Not applicable CERCLA Not applicable California Proposition 65 This product contains the following Proposition 65 chemicals. : 1. >>
BIOACCUMULATIVE POTENTIAL A., and Smith, P. A. SDS.
JRS Pharma: PROSOLV SMCC 90: Microcrystalline Cellulose, Colloidal Silicon Dioxide: 125: 0.25 - 0.37: Formulas in which a balance of flow and compaction is required. F. Lerk, G.K. Bolhuis, A.H. De Boer, Effect of Microcrystalline Cellulose on liquid penetration in and disintegration of directly compressed tablets, Journal of Pharmaceutical Sciences, 68 (1979) 205-211. Upon ingestion, microcrystalline cellulose is not absorbed into the blood stream and therefore has little toxicological potential. SCMm_>x^O9l (n. microcrystalline cellulose and carboxymethylcellulose sodium NF, Ph. CAS 9004-34-6, pH 5 - 7.5.
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PRODUCT AND COMPANY IDENTIFICATION PRODUCT NAME: Avicel PC 611 Microcrystalline Cellulose CHEMICAL FAMILY: Carbohydrate, Cellulose Derivative SYNONYMS: Microcrystalline cellulose (INCI name): MCC, cellulose gel; Sodium Carboxymethylcellulose: NaCMC, CMC, SCMC, Carboxymethylcellulose GENERAL USE: Personal Care MANUFACTURER
FMC BioPolymer 1735 Market Street Philadelphia, PA 19103 (800) 526-3649 (General Information) msdsinfo@fmc.com (Email - General Information)
FMC Europe NV Avenue Mounier 83 1200 Brussels, Belgium 353 21 435 4133 (General Information - Cork, Ireland) 2. Millipore. However, it yields non-digestible fibre. xv}O2' H~KEe9>G/,:9\i gwf;J(e0o|1p{R~P^);ao!%{0KD7. The most. Earth Supplied Products LLC. Product name: Microcrystalline cellulose; CBnumber: CB4217972; CAS: 9004-34-6; EINECS Number: 232-674-9; Synonyms: MICROCRYSTALLINE CELLULOSE,cellulose;
Microcrystalline Cellulose (Inactive Ingredient) - Drugs.com There have always been two different points of view for the liquidity of MCC. It can be processed both via wet granulation and direct compression, as well as roller compression and extrusion-spheronisation. PDF (2.77 mb) 2021 FMC Sustainability Report.
They are white to off-white, free-flowing hydrophilic powders supplied in a variety of viscosity grades corresponding to approximate molecular weight, ranging from 100,000 to 7,000,000 daltons. Apply today! TEXTURECEL is highly purified sodium carboxymethyl cellulose (NaCMC) that forms clear solutions in water at all temperatures, has exceptional water binding properties, and is available in a wide range of viscosity grades. /Producer(Sub Systems, Inc.)/CreationDate(D:20181207095625+05'00')/ModDate(D:20181207095625+05'00')/Creator(Sub Systems, Inc.)
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qaj/QU<5OrVMfl{pL? These co-processed products are designed to solve complex formulation problems, simplify manufacturing processes, and deliver significant cost savings. An internally cross-linked sodium carboxymethyl cellulose (NaCMC), it aids in the disintegration and drug dissolution of pharmaceutical tablets, capsules, and granules.
PDF Safety Data Sheet - Fmc For this reason, nutritionists regard standard powdered microcrystalline cellulose as having zero energy content. Place an order online, track your orders, download SDS and TDS, and see your quotes, all in one secure place. Quick Links. In 1964 FMC, Corporation . More than 65 years later, Avicel continues to command global acceptance, with no signs of its popularity waning. Have an order or account question, find answers in our Online Support articles. The main source of cellulose is woody plants, since it is the main building block of the cell walls of higher plants.
PDF Pharma Solutions Avicel Co-Processed Product Selection Guide - DuPont Find answers in our support articles. "l%I-*j|-)@
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kuI?H>$7;!l|g|i4&dtb/O3!C!#\qpg+>Q0OM The highly reactive amorphous regions selectively hydrolyze, releasing the crystallites, which are subsequently mechanically dispersed. High performance lubricant that brings more to the tablet. Report Category. If you have Crohn's disease or a history of bowel obstruction, discuss with a doctor or pharmacist about drug interactions with fiber supplements.. Chemical Formula: (C6H10O5)n 1.4. 1.5% w/w), especially designed for formulating active pharmaceutical ingredients (APIs) with a high sensitivity for moisture. Synonyms: Cellulose, Cellulose powder, Cotton linters. No. (AEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEM %)piQpFNnFu\4m4(
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%QL((((((((((((((((((((((((((((((((((((((((P3NhC G2W4de=u183KGH{ vQ#4:1\wc To overcome the pitfalls of known overlays, we tested suspensions of microcrystalline cellulose Avicel RC/CLtrade mark as overlay media in the plaque and plaque-inhibition assay of influenza viruses. No. Catalog Number 102331. MCC helps in the formation of spheres because of its . ( Cellulose is a linear polymer of -D-glucose, linked through carbon atoms 1 and 4. Chemsrc provides Cellulose microcrystalline(CAS#:9004-34-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. It is insoluble in water, dilute acids, common organic solvents and oils, partially soluble with . msdsinfo@fmc.com (Email - General Information) FMC Europe NV Avenue Mounier 83 1200 Brussels, Belgium 353 21 435 4133 (General Information - Cork, Combinations of microcrystalline cellulose (MCC) and sodium carboxymethyl cellulose (Na-CMC) are commonly used as stabilising agents and suspending agents in pharmaceutical formulations. CAS 9004-34-6. Avicel CL-611 Microcrystalline Cellulose and Sodium Carboxymethylcellulose Page 1 of 9. Avicel Microcrystalline Cellulose: A Guide to Grades and Uses, Working Hours (Mon to Friday): 08:30 - 17:30, legendary Canadian-born chemist, Orlando Aloysius Battista, United States Pharmacopoeia and National Formulary, United States Food and Drug Administration, Quantitative nutritional analysis of Avicel Microcrystalline cellulose (in 100g), https://doi.org/10.1016/0378-5173(95)04231-8, https://doi.org/10.1016/j.ejpb.2004.05.009, https://doi.org/10.1002/9783527682935.ch04, Pharmaceutical Acronyms and Abbreviations, Glossary of Terms Used in the Pharmaceutical Industry, Standard Terms & Conditions Of Sale Of Goods And Services, 4-O-[(1S)-hexopyranosyl]-D-glycero-hexopyranose.
SAFETY DATA SHEET - Fisher Sci Material safety data sheet (MSDS) of the m icrocrystalline cellu lose (MCC) {iy7uEijn0y]"s"gbV~p8Q)zN:cyvs]&,kk=6pcA %iBW|2nKa)Jb7` 0
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e,cqO! Further elaborations can then be performed on the obtained material to produce many other grades of Microcrystalline cellulose. Chemical Formula: (C6H10O5)n 1.4. DC remains the most economical technique to produce large batches of tablets, however its efficacy is directly impacted by the raw material attributes. Alginates from IFF are an excellent choice for consistent performance in a variety of applications. PDF (4.11 mb) Footer menu 1. MATERIAL SAFETY DATA SHEET Avicel PC 611 Microcrystalline Cellulose Page 1 of 8 MSDS Ref. Molecular weight: Not Applicable 1.5. This grade of polymer film remains intact at pH< 6, thus protecting the API in gastric environments. At the same time, its pronounced shear-thinning behavior enables handling of even highly viscous solutions. FMC has deep roots in the food production system worldwide learn more about our latest advances in the future of agriculture.
Microcrystalline Cellulose - an overview | ScienceDirect Topics Regulatory Information It . Fmc Corporation: Ultra-fine microcrystalline cellulose compositions and process . In Cellulose and Cellulose Derivatives in the Food Industry, T. Wstenberg (Ed. Safety Data Sheet (SDS) Viewer. Thus, Avicel contributes no or very few calories to the food system. When selected in wet granulation, the optimum level of use is between 5 and 20%, although higher levels have been successfully used. /PRNewswire/ -- ReportsnReports added Global Microcrystalline Cellulose (MCC) Market Growth 2019-2024 to its online research database.
Avicel PC 611 (FMC Biopolymer) | CosmeticsAndToiletries.com Microcrystalline cellulose (C6H10O5)n is refined wood pulp.
There is a secret ingredient in your burgers: wood pulp - Quartz }[eD-1-8$#Yi^$o8Nc6vwfw;wBT~[Rgi1?%T*/J:/'+Gf'Ae*j@{Rh+2oN|Sbtt;z#v8})F#z=:*]q+U>+ .e
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'yelVnMh=gIYjK:9v{$G;b8=lGG1_,h^0F2`a~Kusz1p#NS*qt6,F:7+Rma-4u} DINFzJ"Mlctg*~HEge Currently, it is marketed both directly and indirectly (through distributors) depending on the country in question. United Nations Sustainable Development Goals, Alginates Protanal, Manucol, Protacid and More, Barrier membrane, Controlled release hydrophilic matrix, Taste masking, Carrageenan Gelcarin, Viscarin and More, Controlled release hydrophilic matrix, Muco-adhesive, Rheology modifier, Rheology modifier/stabilizer, Thin films, Rheology modifier, Rheology modifier/stabilizer, Binder, Controlled release hydrophilic matrix, Rheology modifier, Rheology modifier/stabilizer, Shell - hard capsule, Tablet coatings, Thin films, Topical, Capsules, Other, Solutions, Suspensions, Tablets, Controlled release hydrophilic matrix, Hot melt extrusion, Muco-adhesive, Osmotic pump, Muco-adhesive, Rheology modifier, Rheology modifier/stabilizer, Thin films, Topical. The UK Health & Safety Executive has set workplace exposure limits at 10 mg/m3 long-term (8 hr TWA) for total inhaled dust and 4 mg/m3 for respirable dust. ( MATERIAL SAFETY DATA SHEET. The fumarate moiety of Alubra increases its melting temperature, which allows for greater functionality at high press speeds while the stearate chain maintains the lubricity of the compound and supports low ejection forces. Microcrystalline cellulose (MCC) is one of the most important tableting excipients thanks to its outstanding dry binding properties, enabling the manufacture of tablets by direct compression (DC). Explore how you can develop your career and bring your creative ideas to life at IFF. Meet our leadership team.
PDF Material Safety Data Sheet - FMC Copyright 2023 by International Flavors & Fragrances Inc. IFF is a Registered Trademark.
Comprecel|MINGTAI CHEMICAL Your file is uploaded and ready to be published. AFFINISOL HPMC has been specifically designed for generating solid dispersions via spray-drying (SDD) or hot melt extrusion (HME) in the pharmaceutical industry. /Contents 4 0 R
Avicel Microcrystalline Cellulose: Chemical Identifiers. Avicel co-processed products are high functionality excipients offering improved powder flow, granule properties, tablet compression, and mouth feel. Battista, O. B;vLZpHU%ChUyD+[ . Solid dispersions are one of the key technologies for formulating oral solid dosage forms containing APIs with bioavailability challenges. : 160182 Date Approved: 05/25/2010 Revision No. Microcrystalline cellulose (MCC) for industrial purposes is usually obtained from wood pulp and purified cotton linters. Doses up to 30 g per day appear to be . cas:9032-51-3 msds CELLULOSE PAB.
Microcrystalline cellulose (cas 9004-34-6) SDS(Safety Data Sheet) /MSDS <>
PDF Material Safety Data Sheet